Laboratory of Asymmetric Catalysis
The Kalek Research Group

List of Publications

35. N-Heterocyclic carbene-catalyzed olefination of aldehydes with vinyliodonium salts to generate α,β-unsaturated ketones
Rajkiewicz, A. A.; Kalek, M.
Org. Lett., 10.1021/acs.orglett.8b00447.


34. Mechanistic insight into enantioselective palladium-catalyzed oxidative carbocyclization-borylation of enallenes
Qiu Y.; Mendoza, A.; Posevins D.; Himo, F.; Kalek, M.; Bäckvall, J.-E.
Chem. Eur. J. 2018, 24, 2433-2439.


33. Mechanism and selectivity of cooperatively-catalyzed Meyer-Schuster rearrangement/Tsuji-Trost allylic substitution. Evaluation of synergistic catalysis by means of combined DFT and kinetics simulations.
Kalek, M.; Himo, F.
J. Am. Chem. Soc. 2017, 139, 10250-10266. [Open Access pdf]


32. Caution in the use of nonlinear effects as a mechanistic tool for catalytic enantioconvergent reactions: Intrinsic negative nonlinear effects in the absence of higher order species
Kalek, M.; Fu, G. C.
J. Am. Chem. Soc. 2017, 139, 4225-4229.


31. Elucidation of mechanisms and selectivities of metal-catalyzed reactions using quantum chemical methodology
Santoro, S.; Kalek, M.; Huang, G.; Himo, F.
Acc. Chem. Res. 2016, 49, 1006-1018. [Open Access pdf]


30. Phosphine-catalyzed doubly stereoconvergent γ-additions of racemic heterocycles to racemic allenoates: the catalytic enantioselective synthesis of protected α,α-disubstituted α-amino acid derivatives
Kalek, M.; Fu, G. C.
J. Am. Chem. Soc. 2015, 137, 9438-9442. [Open Access pdf]


29. Phosphine-catalyzed enantioselective intramolecular [3+2] cycloadditions to generate fused ring systems
Lee S. Y.; Fujiwara, Y.; Nishiguchi, A.; Kalek, M.; Fu, G. C.
J. Am. Chem. Soc. 2015, 137, 4587-4591. [Open Access pdf]


28. Mechanism, reactivity, and selectivity of iridium-catalyzed C(sp3)-H borylation of chlorosilanes
Huang, G.; Kalek, M.; Liao, R.-Z.; Himo, F.
Chem. Sci. 2015, 6, 1735-1746. [Open Access pdf]


27. Atom-efficient gold(I) chloride-catalyzed synthesis of alpha-sulfenylated carbonyl compounds from propargylic alcohols and aryl thiols: substrate scope and combined experimental and computational mechanistic investigation
Biswas, S.; Dahlstrand, C.; Watile, R. A.; Kalek, M.; Himo, F.; Samec, J. S. M.
Chem. Eur. J. 2013, 19, 17939–17950. [Open Access pdf]


26. Mechanism and selectivity of rhodium-catalyzed 1:2 coupling of aldehydes and allenes
Huang, G.; Kalek, M.; Himo, F.
J. Am. Chem. Soc. 2013, 135, 7647-7659. [Open Access pdf]


25. Combining Meyer-Schuster rearrangement with aldol and Mannich reactions – DFT study of the intermediate interception strategy
Kalek, M.; Himo, F.
J. Am. Chem. Soc. 2012, 134, 19159-19169.


24. Computational study of the mechanism and selectivity of palladium-catalyzed SN2’ propargylic substitution with phosphorus nucleophiles
Jiménez-Halla, J. O. C.; Kalek, M.; Stawinski, J.; Himo, F.
Chem. Eur. J. 2012, 18, 12424-12436.


23. 31P NMR and computational studies on stereochemistry of conversion of phosphoramidate diesters into the corresponding phosphotriesters
Söderberg, L.; Lavén, G.; Kalek, M.; Stawinski, J.
Nucleosides Nucleotides Nucleic Acids 2011, 30, 552-564.

22. Novel, stereoselective and stereospecific synthesis of allenylphosphonates and related compounds via palladium-catalyzed propargylic substitution
Kalek, M.; Stawinski, J.
Adv. Synth. Catal. 2011, 353, 1741-1755.


21. Palladium-catalyzed propargylic substitution with phosphorus nucleophiles: efficient, stereoselective synthesis of allenylphosphonates and related compounds
Kalek, M.; Johansson, T.; Jezowska, M.; Stawinski, J.
Org. Lett. 2010, 12, 4702-4704.


20. Preparation of benzylphosphonates via a palladium(0)-catalyzed cross-coupling of H-phosphonate diesters with benzyl halides. Synthetic and mechanistic studies.
Lavén, G.; Kalek, M.; Jezowska, M.; Stawinski, J.
New J. Chem. 2010, 34, 967-975.


19. Preparation of arylphosphonates by Pd(0)-catalyzed cross-coupling in the presence of acetate additives. Synthetic and mechanistic studies.
Kalek, M.; Jezowska, M.; Stawinski, J.
Adv. Synth. Catal. 2009, 351, 3207-3216.


18. Efficient synthesis of mono- and diarylphosphinic acids: a microwave-assisted palladium-catalyzed cross-coupling of aryl halides with phosphinate
Kalek, M.; Stawinski, J.
Tetrahedron 2009, 65, 10406-10412.


17. On the sulfurization of H-phosphonate diesters and phosphite triesters using elemental sulfur
Wallin, R.; Kalek, M.; Bartoszewicz, A.; Thelin, M.; Stawinski, J.
Phosphorus, Sulfur Silicon Relat. Elem. 2009, 184, 908-916.

16. Microwave-assisted palladium-catalyzed cross-coupling of aryl and vinyl halides with H-phosphonate diesters
Kalek, M.; Ziadi, A.; Stawinski, J.
Org. Lett. 2008, 10, 4637-4640.


15. Iodine-promoted silylation of alcohols with silyl chlorides. Synthetic and mechanistic studies.
Bartoszewicz, A.; Kalek, M.; Stawinski, J.
Tetrahedron 2008, 64, 8843-8850.


14. Palladium-catalyzed C-P bond formation: mechanistic studies on the ligand substitution and the reductive elimination. An intramolecular catalysis by the acetate group in Pd(II) complexes.
Kalek, M.; Stawinski, J.
Organometallics 2008, 27, 5876-5888.


13. The case for the intermediacy of monomeric metaphosphates during oxidation of H-phosphonothioate, H-phosphonodithioate, and H-phosphonoselenoate monoesters. Mechanistic and synthetic studies.
Bartoszewicz, A.; Kalek, M; Stawinski, J.
J. Org. Chem. 2008, 73, 5029-5038.


12. mRNA decapping is promoted by an RNA binding channel in Dcp2
Deshmukh, M. V.; Jones, B. N.; Quang-Dang, D.; Flinders, J. C.; Floor, S. N.; Kim, C.; Jemielity, J.; Kalek, M.; Darzynkiewicz, E.; Gross J. D.
Mol. Cell 2008, 29, 324-336.

11. Identification of efficient and sequence specific bimolecular artificial ribonucleases by a combinatorial approach
Kalek, M.; Benedikson, P.; Vester, B.; Wengel, J.
Chem. Commun. 2008, 762-764.


10. A new reagent system for efficient silylation of alcohols – silyl chloride-N-methylimidazole-iodine
Bartoszewicz, A.; Kalek, M.; Nilsson, J.; Hiresova, R.; Stawinski, J.
Synlett 2008, 37-40.


9. Kinetics of C. Elegans DcpS cap hydrolysis studied by fluorescence spectroscopy
Wierzchowski, J.; Pietrzak, M.; Stepinski, J.; Jemielity, J.; Kalek, M.; Bojarska, E.; Jankowska-Anyszka, M; Davis, R. E.; Darzynkiewicz, E.
Nucleosides Nucleotides Nucleic Acids 2007, 26, 1211-1215.

8. Interaction of human decapping scavenger with 5' mRNA cap analogues: structural requirements for catalytic activity
Darzynkiewicz, Z. M.; Bojarska, E.; Kowalska, J.; Lewdorowicz, M; Jemielity, J.; Kalek, M.; Stepinski, J.; Davis R. E.; Darzynkiewicz E.
J. Phys.: Condens. Matter 2007, 19, 285217.

7. Pd(0)-catalyzed phosphorus-carbon bond formation. Mechanistic and synthetic studies on the role of the palladium sources and anionic additives.
Kalek, M.; Stawinski, J.
Organometallics 2007, 26, 5840-5847.


6. Effective modulation of DNA-duplex stability by reversible transition metal complex formation in the minor groove
Kalek, M.; Madsen, A. S.; Wengel, J.
J. Am. Chem. Soc. 2007, 129, 9392-9400.


5. Enzymatically stable 5’ mRNA cap analogs: synthesis and binding studies with human DcpS decapping enzyme
Kalek, M.; Jemielity, J.; Darzynkiewicz, Z. M.; Bojarska, E.; Stepinski, J.; Stolarski, R.; Davies, R. E.; Darzynkiewicz, E.
Bioorg. Med. Chem. 2006, 14, 3223-3330.


4. Differential inhibition of mRNA degradation pathways by novel cap analogs
Grudzien, E.; Kalek, M.; Jemielity, J.; Darzynkiewicz, E.; Rhoads, R. E.
J. Biol. Chem. 2006, 281, 1857-1867.

3. Synthesis and biochemical properties of novel mRNA 5’ cap analogs resistant to enzymatic hydrolysis
Kalek, M.; Jemielity, J.; Grudzien, E.; Zuberek, J.; Bojarska, E.; Cohen, L. S.; Stepinski, J.; Stolarski, R.; Davies, R. E.; Rhoads, R. E.; Darzynkiewicz, E.
Nucleosides Nucleotides Nucleic Acids 2005, 24, 615-621.

2. Novel dinucleoside 5’,5’-triphosphate cap analogues and affinity for murine translation factor eIF4E
Stepinski, J.; Zuberek, J.; Jemielity, J.; Kalek, M.; Stolarski, R.; Darzynkiewicz, E.
Nucleosides Nucleotides Nucleic Acids 2005, 24, 629-633.

1. A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides
Kalek, M.; Jemielity, J.; Stepinski, J.; Stolarski, R.; Darzynkiewicz, E.
Tetrahedron Lett. 2005, 46, 2417-2421.


Book Chapters

1. Stereoselective methods for carbon-phosphorus (C–P) bond formation
Kalek, M.; Stawinski, J.
in Stereoselective Synthesis of Drugs and Natural Products; Andrushko, V. and Andrushko, N. (Eds.)
John Wiley & Sons, 2013 (ISBN 978-1-118-03217-6), pp. 1443-1472.

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